{"id":27766,"date":"2021-01-19T04:10:59","date_gmt":"2021-01-19T04:10:59","guid":{"rendered":"https:\/\/pr.asianetpakistan.com\/?p=69108"},"modified":"2021-01-19T04:10:59","modified_gmt":"2021-01-19T04:10:59","slug":"taconic-biosciences-expande-o-portfolio-de-modelos-animais-de-imuno-oncologia","status":"publish","type":"post","link":"https:\/\/southafricajournal.com\/taconic-biosciences-expande-o-portfolio-de-modelos-animais-de-imuno-oncologia\/","title":{"rendered":"Taconic Biosciences Expande o Portf\u00f3lio de Modelos Animais de Imuno-oncologia"},"content":{"rendered":"

Hospedeiro de Modelo de Tumor Sing\u00eanico Jh Cr\u00edtico Agora Dispon\u00edvel em um Fundo B6<\/h4>\n

RENSSELAER, NY, Jan. 18, 2021 (GLOBE NEWSWIRE) — A Taconic Biosciences, l\u00edder global no fornecimento de solu\u00e7\u00f5es de modelo de animais para a descoberta de medicamentos, anuncia a expans\u00e3o do portf\u00f3lio de imuno-oncologia.<\/p>\n

A imuno-oncologia \u00e9 uma prioridade de pesquisa l\u00edder porque usa o pr\u00f3prio sistema imunol\u00f3gico do corpo para tratar eficazmente alguns tipos de c\u00e2ncer. Os modelos animais de tumor sing\u00eanico desempenham um papel essencial porque usam camundongos endog\u00e2micos padr\u00e3o que t\u00eam um sistema imunol\u00f3gico competente, o que \u00e9 necess\u00e1rio para avaliar terapias imunomoduladoras. Estes modelos s\u00e3o enxertados com tumores de camundongo derivados do mesmo fundo de cepa; esta semelhan\u00e7a gen\u00e9tica entre tumor e hospedeiro impede que o hospedeiro rejeite o tumor.<\/p>\n

Uma considera\u00e7\u00e3o no uso de modelos sing\u00eanicos \u00e9 que alguns candidatos a medicamentos podem causar uma resposta imune negativa n\u00e3o observada em humanos.\u00a0\u00a0 Camundongos padr\u00e3o podem desenvolver anticorpos antidrogas (ADA), que podem neutralizar a terapia ou at\u00e9 mesmo desencadear anafilaxia. Isso pode impedir que os pesquisadores determinem a efic\u00e1cia terap\u00eautica em um estudo pr\u00e9-cl\u00ednico.<\/p>\n

O camundongo Jh<\/a> da Taconic, que n\u00e3o possui c\u00e9lulas B, mas ret\u00eam outros tipos de c\u00e9lulas imunes, como c\u00e9lulas T importantes para avalia\u00e7\u00e3o de imunoterapias, s\u00e3o amplamente utilizados para superar esse problema. Como o camundongo Jh n\u00e3o pode produzir ADA, n\u00e3o h\u00e1 impacto neutralizante ou farmacocin\u00e9tico no risco terap\u00eautico ou de anafilaxia. O camundongo Jh da Taconic era dispon\u00edvel anteriormente apenas no fundo\u00a0BALB\/c<\/u><\/a>, portanto, era aplic\u00e1vel a apenas uma parte dos estudos de tumor sing\u00eanico. O novo camundongo Jh no fundo C57BL\/6 expande a sua utilidade para abranger a maioria dos estudos.<\/p>\n

\u201cA Taconic est\u00e1 empenhada em gerar modelos-chave de camundongos de imuno-oncologia e facilitar o acesso a eles para a descoberta de medicamentos\u201d, compartilhou o Dr. Michael Seiler, vice-presidente de modelos comerciais da Taconic. “O camundongo Jh est\u00e1 dispon\u00edvel globalmente para pesquisadores sem fins lucrativos e com fins lucrativos, incluindo organiza\u00e7\u00f5es de pesquisa sob contrato.\u201d<\/p>\n

Coortes de camundongos Jh de vers\u00f5es\u00a0 C57BL\/6<\/u><\/a>\u00a0e\u00a0BALB\/c<\/u><\/a> est\u00e3o dispon\u00edveis para entrega imediata.<\/p>\n

Os modelos Jh s\u00e3o apenas um aspecto do\u00a0portf\u00f3lio de imuno-oncologia<\/u><\/a> da Taconic, que inclui camundongos humanizados criados com base no\u00a0CIEA NOG mouse\u00ae<\/u><\/a> imunodeficiente, \u00a0al\u00e9m de solu\u00e7\u00f5es\u00a0personalizadas de gera\u00e7\u00e3o de modelos<\/u><\/a>\u00a0e\u00a0solu\u00e7\u00f5es de gerenciamento de col\u00f4nias<\/u><\/a>.<\/p>\n

Para mais informa\u00e7\u00e3o sobre camundongos Jh, ligue para a Taconic 1-888-TACONIC (888-822-6642) nos EUA, +45 70 23 04 05 na Europa, ou envie email para\u00a0info@taconic.com<\/u><\/a>.<\/p>\n

Sobre a Taconic Biosciences, Inc.<\/p>\n

A Taconic Biosciences \u00e9 uma l\u00edder global totalmente licenciada em servi\u00e7os e modelos geneticamente modificados. Fundada em 1952, a Taconic oferece as melhores solu\u00e7\u00f5es \/ modelos de pesquisas em murinos, para que os clientes possam adquirir, customizar, criar, pr\u00e9-condicionar, testar e distribuir valiosos modelos de pesquisa em todo o mundo. Especializada em modelos de camundongos e de ratos geneticamente projetados, microbioma, modelos de camundongos imuno-oncologia, e servi\u00e7os de design e cria\u00e7\u00e3o de modelos integrados, a Taconic opera tr\u00eas laborat\u00f3rios de servi\u00e7os e seis instala\u00e7\u00f5es de cria\u00e7\u00e3o nos EUA e na Europa, mant\u00e9m rela\u00e7\u00f5es com distribuidores na \u00c1sia e tem capacidades de entrega em n\u00edvel global para oferecer modelos em quase qualquer lugar no mundo.<\/p>\n

Contato da M\u00eddia:<\/p>\n

Kelly Owen Grover
\nDiretora de Comunica\u00e7\u00f5es de Marketing
\n518-478-6095
\nkelly.grover@taconic.com<\/u><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Hospedeiro de Modelo de Tumor Sing\u00eanico Jh Cr\u00edtico Agora Dispon\u00edvel em um Fundo B6 RENSSELAER, NY, Jan. 18, 2021 (GLOBE NEWSWIRE) \u2014 A Taconic Biosciences, l\u00edder global no fornecimento de solu\u00e7\u00f5es de modelo de animais para a descoberta de medicamentos, anuncia a expans\u00e3o do portf\u00f3lio de imuno-oncologia. A imuno-oncologia \u00e9 uma prioridade de pesquisa l\u00edder [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"yoast_head":"\nTaconic Biosciences Expande o Portf\u00f3lio de Modelos Animais de Imuno-oncologia - South Africa Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/southafricajournal.com\/taconic-biosciences-expande-o-portfolio-de-modelos-animais-de-imuno-oncologia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Taconic Biosciences Expande o Portf\u00f3lio de Modelos Animais de Imuno-oncologia - South Africa Journal\" \/>\n<meta property=\"og:description\" content=\"Hospedeiro de Modelo de Tumor Sing\u00eanico Jh Cr\u00edtico Agora Dispon\u00edvel em um Fundo B6 RENSSELAER, NY, Jan. 18, 2021 (GLOBE NEWSWIRE) \u2014 A Taconic Biosciences, l\u00edder global no fornecimento de solu\u00e7\u00f5es de modelo de animais para a descoberta de medicamentos, anuncia a expans\u00e3o do portf\u00f3lio de imuno-oncologia. 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