{"id":46437,"date":"2022-10-24T13:08:14","date_gmt":"2022-10-24T13:08:14","guid":{"rendered":"https:\/\/pr.asianetpakistan.com\/?p=100599"},"modified":"2022-10-24T13:08:14","modified_gmt":"2022-10-24T13:08:14","slug":"taconic-biosciences-lance-le-premier-et-le-seul-modele-de-souris-super-immunodeficientes-depourvus-de-recepteurs-fc-gamma-murins-residuels-pour-une-evaluation-amelioree-de-la-therapie-par-anticorps","status":"publish","type":"post","link":"https:\/\/southafricajournal.com\/taconic-biosciences-lance-le-premier-et-le-seul-modele-de-souris-super-immunodeficientes-depourvus-de-recepteurs-fc-gamma-murins-residuels-pour-une-evaluation-amelioree-de-la-therapie-par-anticorps\/","title":{"rendered":"Taconic Biosciences lance le premier et le seul mod\u00e8le de souris super immunod\u00e9ficientes d\u00e9pourvus de r\u00e9cepteurs Fc Gamma murins r\u00e9siduels, pour une \u00e9valuation am\u00e9lior\u00e9e de la th\u00e9rapie par anticorps"},"content":{"rendered":"<div>\n<h4 align=\"center\">Les mod\u00e8les FcResolv<img decoding=\"async\" src=\"https:\/\/s.w.org\/images\/core\/emoji\/14.0.0\/72x72\/2122.png\" alt=\"\u2122\" class=\"wp-smiley\" style=\"height: 1em; max-height: 1em;\" \/> NOG offrent une plus grande clart\u00e9 et des donn\u00e9es plus traduisibles<\/h4>\n<p>RENSSELAER, New York, 24 oct. 2022 (GLOBE NEWSWIRE) &#8212; Taconic Biosciences, un leader mondial dans la fourniture de solutions de mod\u00e8les animaux pour la d\u00e9couverte de m\u00e9dicaments, a lanc\u00e9 le portefeuille FcResolv<img decoding=\"async\" src=\"https:\/\/s.w.org\/images\/core\/emoji\/14.0.0\/72x72\/2122.png\" alt=\"\u2122\" class=\"wp-smiley\" style=\"height: 1em; max-height: 1em;\" \/> NOG, les premiers et seuls mod\u00e8les de souris super immunod\u00e9ficientes d\u00e9pourvus de r\u00e9cepteurs Fc Gamma murins r\u00e9siduels (FcyRs) connus pour fausser les r\u00e9sultats dans les \u00e9tudes th\u00e9rapeutiques \u00e0 base d&#8217;anticorps.<\/p>\n<p>Les FcyRs murins peuvent provoquer de faux positifs ou de faux n\u00e9gatifs, ce qui conduit \u00e0 des conclusions erron\u00e9es et fait d\u00e9railler la d\u00e9couverte de m\u00e9dicaments. Les mod\u00e8les FcResolv NOG \u00e9liminent ces r\u00e9cepteurs pour une plus grande clart\u00e9 dans les \u00e9tudes m\u00e9dicamenteuses \u00e0 base d&#8217;anticorps, offrant aux chercheurs une plus grande confiance et des donn\u00e9es plus traduisibles avec moins d&#8217;\u00e9tudes et moins d&#8217;animaux. Avec une applicabilit\u00e9 en oncologie, en immuno-oncologie et en maladie auto-immune, les mod\u00e8les FcResolv NOG sont adapt\u00e9s \u00e0 la greffe d&#8217;un large \u00e9ventail de cellules et tissus humains, y compris la greffe de tumeurs humaines simultan\u00e9e et l&#8217;humanisation du syst\u00e8me immunitaire.<\/p>\n<p>\u00ab\u00a0Les th\u00e9rapies \u00e0 base d&#8217;anticorps repr\u00e9sentent l&#8217;une des classes de m\u00e9dicaments \u00e0 la croissance la plus rapide, cr\u00e9ant un besoin urgent de meilleurs outils pr\u00e9cliniques pour \u00e9valuer des traitements tels que les anticorps monoclonaux, les conjugu\u00e9s anticorps-m\u00e9dicaments et les anticorps bisp\u00e9cifiques\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr\u00a0Michael Seiler, vice-pr\u00e9sident des produits commerciaux chez Taconic. \u00ab\u00a0Le portefeuille de r\u00e9cepteurs FcResolv NOG de Taconic permet aux chercheurs d&#8217;\u00e9valuer des m\u00e9dicaments candidats tels que ceux-ci selon leurs propres m\u00e9rites, sans interf\u00e9rence de l&#8217;activit\u00e9 r\u00e9siduelle du r\u00e9cepteur Fc Gamma murin.\u00a0\u00bb<\/p>\n<p>Les mod\u00e8les FcResolv NOG \u00e9liminent les faux n\u00e9gatifs qui se produisent lorsqu&#8217;un domaine\u00a0Fc th\u00e9rapeutique \u00e0 base d&#8217;anticorps interagit avec les FcyRs murins, ainsi que les faux positifs qui en r\u00e9sultent lorsque les FcyRs d\u00e9clenchent une activit\u00e9 immunitaire murine r\u00e9siduelle. Ils \u00e9liminent \u00e9galement les \u00e9tapes de d\u00e9convolution co\u00fbteuses n\u00e9cessaires pour distinguer une v\u00e9ritable efficacit\u00e9 m\u00e9dicamenteuse des effets hors cible induits par le syst\u00e8me immunitaire de la souris. Gr\u00e2ce \u00e0 des r\u00e9ponses plus fiables, les chercheurs peuvent cibler leurs investissements dans la d\u00e9couverte de m\u00e9dicaments de mani\u00e8re plus strat\u00e9gique et plus efficace.<\/p>\n<p>Le portefeuille de mod\u00e8les NOG FcResolv est bas\u00e9 sur la souris<sup>\u00ae<\/sup> NOG CIEA super immunod\u00e9ficiente. Le portefeuille comprend actuellement deux mod\u00e8les\u00a0:<\/p>\n<ul type=\"disc\">\n<li><strong>FcResolv NOG, <\/strong>pour les x\u00e9rogreffes tumorales utilisant des lign\u00e9es cellulaires ou des tumeurs d\u00e9riv\u00e9es des patients, la greffe d&#8217;autres cellules et tissus humains normaux ou pathologiques, et les \u00e9tudes d&#8217;humanisation du syst\u00e8me immunitaire<\/li>\n<li><strong>FcResolv hIL-15 NOG<\/strong>, qui supporte la greffe des cellules\u00a0NK humaines et convient pour des \u00e9tudes d&#8217;efficacit\u00e9 sur les th\u00e9rapies \u00e0 base d&#8217;anticorps avec un m\u00e9canisme d&#8217;action de cytotoxicit\u00e9 cellulaire d\u00e9pendant des anticorps (ADCC)<\/li>\n<\/ul>\n<p>Pour en savoir plus sur le portefeuille de FcResolv NOG, rendez-vous sur <a href=\"https:\/\/www.google.com\/url?q=https:\/\/www.globenewswire.com\/Tracker?data%3DzbNLXfG-mOiSVy3XPWHnJNKzAedXv7dw_7lx2giAxir_sBiF_qQgdBxr5XnDetc0opxgsytgBkK02VuVHOcSOofgQxztiuHFkJjV7h8luVA%3D&amp;source=gmail-html&amp;ust=1666703227023000&amp;usg=AOvVaw1zYamgtZeS9-9AYeHrl10B\"  rel=\"nofollow noopener noreferrer\"><u>www.Taconic.com\/fcresolv<\/u><\/a>. Vous pouvez \u00e9galement appeler le 1-888-TACONIC (888-822-6642) aux \u00c9tats-Unis, le +45 70 23 04 05 en Europe, ou envoyer un e-mail \u00e0 l&#8217;adresse <a href=\"https:\/\/www.google.com\/url?q=https:\/\/www.globenewswire.com\/Tracker?data%3DkQjrtQISc1mykL-6U7l5zuJGyq8YhLDgV2u8EQPzNepHTjfaVYlwg1CyiNmtHZ9xLG0pQizRVriEEQbSRvsqBA%3D%3D&amp;source=gmail-html&amp;ust=1666703227023000&amp;usg=AOvVaw3tYa38JnoQ458XMDaAhBJE\"  rel=\"nofollow noopener noreferrer\"><u>info@taconic.com<\/u><\/a>.<\/p>\n<p><strong>\u00c0 propos de Taconic Biosciences, Inc.<\/strong><\/p>\n<p>Taconic Biosciences est un leader mondial pleinement agr\u00e9\u00e9 dans les mod\u00e8les et les services de rongeurs g\u00e9n\u00e9tiquement modifi\u00e9s. Fond\u00e9e en 1952, Taconic offre les meilleures solutions animales afin que les clients puissent acqu\u00e9rir, g\u00e9n\u00e9rer d&#8217;une mani\u00e8re personnalis\u00e9e, \u00e9lever, pr\u00e9-conditionner, tester et distribuer des mod\u00e8les de recherche pr\u00e9cieux dans le monde entier. Sp\u00e9cialiste des mod\u00e8les de souris et de rats g\u00e9n\u00e9tiquement modifi\u00e9s, du microbiome, des mod\u00e8les de souris pour l&#8217;immuno-oncologie et des services de conception de mod\u00e8les int\u00e9gr\u00e9s et d&#8217;\u00e9levage, Taconic exploite des laboratoires de services et des \u00e9tablissements d&#8217;\u00e9levage aux \u00c9tats-Unis et en Europe, entretient des relations de distribution en Asie et dispose de capacit\u00e9s d&#8217;exp\u00e9dition mondiales pour fournir des mod\u00e8les animaux presque partout dans le monde.<\/p>\n<p><strong>Contact aupr\u00e8s des m\u00e9dias\u00a0:<\/strong><\/p>\n<p>Louise Baskin, directrice principale du nouveau Pipeline de produits<\/p>\n<p>303-432-2495<\/p>\n<p><a href=\"https:\/\/www.google.com\/url?q=https:\/\/www.globenewswire.com\/Tracker?data%3DQqLeE_Pmr4scO1Kn-WjZLK9H2FVBq5sTzkJYIwZtImTNY3GumM0rzcREDfGgrRfjFWXsPuXdommxGrVLKKp-6IKNckPROKqkqIyXZC2U6XI%3D&amp;source=gmail-html&amp;ust=1666703227023000&amp;usg=AOvVaw32I3HKvYud6mE5KdSO58Aq\"  rel=\"nofollow noopener noreferrer\"><u>Louise.Baskin@taconic.com<\/u><\/a><\/p>\n<p style=\"text-align: center;\">GlobeNewswire Distribution ID 8670426<\/p>\n<p><img decoding=\"async\" class=\"m___GNW8366DE3E__IMG\" src=\"https:\/\/ci6.googleusercontent.com\/proxy\/xAd9qfUdKukFBlDnm0vdmhZ-kJiKNyWOqVU5xZuBNabb7D5UkzvRAskPWqq0YHOcM5NgYOib4uF7fbkmfJl1jeX4drtJdgKSJo5xqgKHrh42eYYnyQgOWIp17FPJ4r0y=s0-d-e1-ft#https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODY3MDQyNiM1MjE4NTE1IzIwODQ0NzQ=\" \/><br \/>\n<img decoding=\"async\" src=\"https:\/\/ci4.googleusercontent.com\/proxy\/qNIS3Zg9FJ8_G2D6k17xfLk7PrP-ay3ZRjWoI8iV9uzsGNY-pefRmOStD0RTAqYb0vy4FnqTs2FSu3mfo_XBXgU96tTFEjhFJbP-mnosRUrmb70vLUfsCBuhxWwlcM9diwa-BJ51qSm9YFn7nOeQTNMbp0Qxoy7rwGN2RmoQpG22iRW0GlCbJOxGmxes00g=s0-d-e1-ft#https:\/\/ml.globenewswire.com\/media\/NzYwNzk2NTEtNjcxYy00YzJhLTgwNTktM2M5ZjczMTAxZTE1LTEwOTYwNDU=\/tiny\/Taconic-Biosciences.png\" \/><\/p>\n<p align=\"center\">\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Les mod\u00e8les FcResolv\u2122 NOG offrent une plus grande clart\u00e9 et des donn\u00e9es plus traduisibles RENSSELAER, New York, 24 oct. 2022 (GLOBE NEWSWIRE) \u2014 Taconic Biosciences, un leader mondial dans la fourniture de solutions de mod\u00e8les animaux pour la d\u00e9couverte de m\u00e9dicaments, a lanc\u00e9 le portefeuille FcResolv\u2122 NOG, les premiers et seuls mod\u00e8les de souris super [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Taconic Biosciences lance le premier et le seul mod\u00e8le de souris super immunod\u00e9ficientes d\u00e9pourvus de r\u00e9cepteurs Fc Gamma murins r\u00e9siduels, pour une \u00e9valuation am\u00e9lior\u00e9e de la th\u00e9rapie par anticorps - South Africa Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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